Its been so long, said Stanford, also the 2003 ShopRite LPGA Classic winner.
The 30-year-old Texan, four strokes ahead entering the day after consecutive 67s in the second and third rounds, had an 11-under 277 total on the Crossings Course at Magnolia Grove. She earned $210,000.
The 19-year-old Feng birdied the 18th for a 68.
Kim Hall was third at 8 under after a 69, and Hee Young Park (70), Danielle Downey (70) and Katherine Hull (73) followed at 7 under.
Stanford had four birdies, three bogeys and double bogey in the final round.
Im more relieved than excited. Im just relieved that I did it again, Stanford said. I honestly believe the second time is harder, because the first time you dont really know whats happening and then you just try to do it again. Ive been trying, and probably too hard.
Sanford missed a 3-foot putt for birdie on 17 and a 12-foot birdie try on 18 before make the 3 1/2 -footer for par to claim the title.
After the putt, she dropped her putter and turned and hugged caddie Dan Chapman. Fellow players Brittany Lincicome and Kristy McPherson then ran onto the green and showered her with champagne.
I didnt get that my first time, Stanford said of the shower. I won (the first time) in my third year and I feel like Im a different person now. I think its with anybody, you kind of grow up. Youve seen a lot of peaks and valleys in five years.
Feng had her chances to earn her first career win, lipping out on a putt for eagle on 16. She did eagle the fourth hole, her fourth eagle of the tournament and second on the 448-yard, par-5 hole. She also eagled 16 twice.
I was pretty nervous at the last hole because I had a chance to win, but I had to make birdie, said Feng, who shared the first-round lead. I was very happy, but I knew thats what I could do. I did my best. I really want to win, but I know Im still young so Ill have my chances.