Tiger Woods and Vijay Singh were shown the door in the second round, then Phil Mickelson followed in the third. Only Retief Goosen, the two-time U.S. Open winner, advanced to the quarterfinals at La Costa Resort & Spa.
In the afternoon's third round, Mickelson, the top seed in the Sam Snead bracket, got trounced by fourth seed, David Toms, 4 and 2. Toms will now meet third-seeded Adam Scott in Saturday's quarterfinals after the Aussie dispatched second seed Sergio Garcia, 4 and 3.
Goosen, the top-ranked player in the Ben Hogan bracket, birdied the first extra hole to best Chad Campbell. Campbell played 43 holes on Friday as his second-round match with Miguel Angel Jimenez went 24 holes. Goosen gets Robert Allenby, the 11th seed, after a 2 and 1 win over Kirk Triplett.
O'Hern, seeded eighth, continued his fine form in the third round as he posted a 5 and 4 drubbing of fifth seed Luke Donald. O'Hern will meet 11th-seeded Ian Poulter, who made it to the quarterfinals last year. Poulter won the 16th and 17th holes for a 1-up victory over Rory Sabbatini.
Singh's bracket became an American battle once the No. 1 player in the game was eliminated. Haas, 51, could not get by Chris DiMarco in the third round as DiMarco put up a 2 and 1 win.
DiMarco will meet second-seeded Stewart Cink on Saturday. Cink holed a clutch birdie putt on 18 to force extra holes, then parred the second playoff hole to defeat last year's runner-up Davis Love III.
The tournament is back on schedule after Wednesday's first-round action was wiped out due to heavy rain in the area. Both the second and third rounds were contested on Friday and the quarterfinals and semifinals are on tap for Saturday.
The Sam Snead bracket separated itself as the top-four seeds moved on to the third round.
The Mickelson/Toms match was even through eight holes, then Mickelson gave away the ninth with a three-putt bogey. Things got worse for Mickelson, who won his last two starts on the PGA Tour.
He dropped the 10th to a Toms birdie, then got an unfortunate break at the par-5 11th. Mickelson's second bounced into the thick rough and the reigning Masters champion slashed his third a few feet closer to the hole. He made par, but Toms made birdie and went 3 up.
Toms, who lost to Woods in the final two years ago, won the 12th with a par and was 4 up. He lost the 14th, but Mickelson conceded the match on the 16th green.
'David shot 7 under so I had to play my best to have any chance. It wasn't enough,' said Mickelson. 'I made a couple of mistakes and you can't afford to do that.'
Toms gets Scott on Saturday and the young Australian is the hottest player left in the field. He captured last week's rain-shortened Nissan Open and has yet to trail in a match this week.
Against Garcia, Scott captured the seventh, eighth and ninth holes to go 3 up. He extended the lead with a 4-foot birdie putt at 11, then polished off the second seed on 15.
'I'm very pleased with my effort today,' said Scott, who won last year's Players Championship. 'I kept the pressure on him.'
Goosen found himself 3 down through 10 holes, but won the 11th with a birdie, was conceded the 14th, then took No. 15 to square the match.
The top seed birdied the first extra hole to keep hope alive for the No. 1 seeds.
In the other third-round match that went extra holes, neither Cink nor Love built a lead larger than 1 up. Love took a 1-up lead with a 15-footer for birdie at 17. Cink answered with a 15-footer of his own at the 18th, then it was on to extra holes.
The pair parred the first hole, then both hit less-than-spectacular tee balls at the par-3 second. Cink blasted out of a trap inside 4 feet, while Love left himself with almost 35 feet for par. Love, the runner-up to Woods in 2004, missed the putt, then conceded the match to Cink
O'Hern now has the reputation of a giant killer with his second-round win, but he had an easier time in round three. Donald and O'Hern both stiffed their approaches at one, but Donald had a little over 2 feet and missed the putt.
Donald missed a series of short putts throughout the match, but got the deficit to 2 down at the ninth. Donald bogeyed 12, 13 and 14 to drop the match.
'It was a very successful day,' said the Australian. 'This morning when I was playing Tiger, it was always going to be a tough match and I just played really solid all day.'