Bolli finished 54 holes at 15-under-par 195, which is good for a three-shot lead. It also matched the tournament's 54-hole record, established by Mark Hensby in 1998.
Ron Whittaker posted a six-under 64 to join Jon Mills, who carded a 3-under 67, in a tie for second place. The pair is knotted at 12-under-par 198 at Hardscrabble Country Club.
Bolli did a lot of his damage early on with three birdies and a bogey in a four-hole span from the third. He rolled in a 25-foot birdie putt at the par-3 eighth to make the turn at 3 under on the day and 11 under par for the championship.
Bolli birdied the par-5 11th, then drained a 20-footer for birdie at No. 12. He polished off three consecutive birdies at the 13th to take the lead of the tournament.
At the par-3 17th, Bolli holed another long birdie putt, another 20-footer to pad his advantage.
It was certainly a good day with the flat stick for Bolli, who made five birdie putts over 18 feet.
'I was definitely in the zone today with the putter, said Bolli, who took 23 putts on Saturday. 'I made a lot in the 10- to 20-foot range. I hit it the same the last two days, but made a lot of putts.'
Bolli has won only once on the Nationwide and that came at the 2004 Chattanooga Classic. That year, he tied for eighth place at the Fort Smith Classic.
'The course is playing different than 2004, but it helps to have played well here before,' said Bolli. 'I like this course. Off the tee you have to hit it straight because of the trees lining the fairways. It has that old course feel.'
Overnight leader Craig Lile only managed an even-par 70 on Saturday. He is tied for fourth place with Garrett Willis (64), David Morland IV (65), Matt Hendrix (65), Scott Dunlap (65), Michael Boyd (68) and Scott Gutschewski (69). The group came in at 11-under-par 199.