Matt Hendrix, playing in his first PGA event of the season, moved into second place at 14-under-par 130 after a second-round 67. Ryan Palmer and Brendan Jones were one stroke further back at minus-13. Mathias Gronberg shares fifth place at 12-under-par 132 with Jason Bohn (68).
Edwards started his second round on the back nine and got off to a good start as his approach shot to the par-4 10th stopped 15 feet from the cup. He rolled in that putt, then parred his next three holes.
The 49-year-old sank another 15-footer for birdie on the 14th. Edwards made the turn at 9 under thanks to a 3-foot birdie putt on the 16th.
Around the turn, he caught fire. The four-time winner on tour rolled in a 25-foot putt for birdie on the first. Edwards made it two in a row as he ran in a 5-footer for birdie.
Edwards stuck his third shot to the par-5 third within a foot of the cup and kicked that in for birdie. He converted a 20-foot birdie putt on the fourth and made it five in a row as he pitched his third to 2 feet at the par-5 fifth.
The Missouri native parred his next three holes. Edwards closed out a bogey-free round by making a 4-foot birdie putt on the ninth at En-Joie Golf Club.
'It was so hot. I guess my game was hot too,' said Edwards of the weather and his play on Friday. 'I hit some good shots and got it close a few times. It feels good to be in this position.'
Hendrix, who shared the opening round lead with Glen Day, began his round on the back nine. He two-putted for birdie on the par-5 12th and did the same after driving the green at the 321-yard, par-4 16th.
The former Clemson all-American sank a 5-foot birdie putt on the 17th to make the turn at 12 under. Hendrix stumbled to a bogey at the first, but rebounded with a birdie on No. 3.
Hendrix two-putted for birdie on the fifth and made it two in a row as he kicked in a birdie putt from inside a foot at the next. Hendrix dropped another shot at the seventh, but atoned for that error with a birdie at the eighth. He parred the last to take second place.
'I just wanted to go out and get a good round under me,' Hendrix said. 'I just wanted to shoot 4 or 5 under to stay close. My distance control and putting have been very good.'
P.H. Horgan III fired a 7-under 65 to move into a tie for seventh place. He was joined at 11-under-par 133 by Mike Springer, Arjun Atwal and Ben Crane.
Chris Smith, Roland Thatcher, Mark Wilson, Bradley Hughes, Day and Jay Delsing were one shot further back at minus-10.
The cut line fell at 4-under-par 140. Among those who missed the cut was 2004 champion Jonathan Byrd.