Furyk ended at 14-under-par 266 for his 12th career win, four months after claiming No. 11 at the Wachovia Championship in May.
It's hard to believe, but this is only the second time in a distinguished career that Furyk has won two PGA TOUR events in one season.
The world No. 3 began the tournament by setting a course record with a 63 on Thursday, though he admitted he wasn't happy with the way he was playing until Sunday.
'I gave myself a lot of opportunities out there,' Furyk said. 'I'd been searching the last couple days for my swing and it kicked in at the right time.'
Furyk, of course, won the 2003 U.S. Open and then claimed the Buick Open two months later. It was the only other time he had multiple wins in a season.
Sunday, he did just enough to fend off Bryant and a slew of other close challengers.
Sean O'Hair, the reigning Rookie of the Year, had a 2-under 68 and finished at 12-under 268. For O'Hair, it was the best finish since he broke through to win the John Deere Classic last year (he tied for fourth at the Buick Open last month).
Brett Quigley, still winless on the PGA TOUR, tied his second-best finish of the season by closing with a 2-under 68. He ended in fourth, one shot behind O'Hair at 268.
Furyk, who was two shots off Justin Rose's lead overnight, had three birdies and a bogey on the front nine to make the turn at 11 under.
He took the lead with a birdie at the 10th, then built a two-shot advantage when he drained a 10-foot birdie putt at the 13th to reach 13 under.
'I wasn't real confident with the way I was striking the ball early on,' Furyk said. 'But from about the seventh or eighth hole, I really struck the ball well.'
Bryant moved within a shot when he chipped in for birdie from the greenside rough at 14. But Furyk drained a 5-foot birdie putt moments later at 17 to restore his two-shot lead.
Furyk then saved par from the rough at the 18th with a gutsy, 30-foot chip in front of the bleachers that landed within 5 feet. He took his time lining up the par putt.
'I was just trying to hit as solid a putt as I could,' he said.
Bryant made a 15-foot birdie putt at the 17th to climb within one shot again, but his approach to the 18th green came up 60 feet short of the hole and he closed with a par.
In the locker room, Furyk watched Bryant make his 15-footer at the 17th.
'It made me a little nervous, but it's nice to finish off the tournament well,' he said.
Rory Sabbatini had a 4-under 66 on Sunday and tied for fifth place with Camilo Villegas (68), Steve Lowery (69), Trevor Immelman (70) and Jonathan Byrd (70).
Playing in the final pairing with Bryant, and still seeking his first PGA TOUR win, Rose struggled to a 4-over 74 and tumbled all the way into a tie for 14th place at 7 under.