Nicolas Colsaerts of Belgium and Spain's Carlos Rodiles posted matching rounds of 66 to finish in a tie for second at 10-under-par 132. Ireland's Paul McGinley was one shot further back at 9-under-par 133.
Goosen torched Saint-Nom-La Breteche Golf Club on Thursday with an opening- round 63 to take the early lead. Nothing much changed for the South African on Friday and Goosen began to pull away from the field after his approach to the par-4 fifth landed in the cup for an eagle.
'I got off to a slow start today and made a good save from the bunker on the third before the eagle really got me going,' said Goosen, who was the runner-up to Sergio Garcia at this event in 2001.
The 2001 U.S. Open champion followed that remarkable shot with a string of three consecutive birdies to jump well ahead of his competitors at 13 under par.
Goosen cooled down on the inward half but tallied a birdie at the par-5 16th to pad his lead.
'Once I get in front I seem to be pretty comfortable there,' said the reigning Order of Merit champion, who has yet to win on the European Tour in 2003.
Rodiles started on the back side and collected four birdies over his first nine holes to make the turn at 9 under.
The 28-year-old stumbled with a bogey at the par-4 first but recovered nicely down the stretch with back-to-back birdies from the eighth. Rodiles remains in contention entering the weekend, but he has plenty of work ahead of him to catch a front-running Goosen at this the last edition of the tournament.
'It's just a pity that this is the last Trophe Lancme,' said Rodiles. 'I like the course and just seem to play well here, although I shot an 80 the first time I played it.'
South Africa's Hennie Otto, who held the first-round lead at this year's British Open Championship, finished six shots off the pace along with Mikael Lundberg of Sweden at 8-under-par 134.
Eduardo Romero of Argentina and Zimbabwe's Mark McNulty were one shot further back at 7-under-par 135.
Padraig Harrington carded a 3-under 68 to join Peter Fowler, Damien McGrane, Ian Poulter, Fredrik Widmark and leading Frenchman Raphael Jacquelin in a tie for ninth at 6-under-par 136.
The 36-hole cut fell at 1-under-par 141 with 81 players qualifying for the weekend. Among those who didn't make the grade was France's Thomas Levet, who lost to Ernie Els in a playoff at the British Open in 2002.