Campbell will take on Irishman Paul McGinley, who handed Angel Cabrera a 4 and 3 defeat in the semifinals.
The top-seeded Goosen entered the semifinal match against Campbell having trailed for only one hole in the his first two matches. That changed dramatically Saturday as the South African never led on this day.
Campbell, the fourth seed, took a 1-up lead with an eagle on the par-5 fourth. He followed that with three consecutive birdies to quickly take a 4-up lead. He stretched that lead to 5-up with a birdie on No. 11.
'I knew I had to bring my 'A' game today and I did,' Campbell said. 'I had a great start to the round with eagle on the fourth and that set the whole mood of the game. But the most important thing was that I couldn't let up and had to keep my foot on the accelerator.'
Goosen finally won his first hole of the match with a chip in birdie on the 14th. However, Campbell birdied the next to regain his 5-up margin. The duo traded the 17th and 18th holes on the West Course at the Wentworth Club as Campbell led 5-up into the afternoon session.
Campbell, who reached the semifinals with wins over Geoff Ogilvy and Steve Elkington, was a lucky winner on the 21st as he took the hole with a bogey. He birdied the 24th and drained a 15-foot birdie putt on the 26th to stretch his lead to 8-up with 10 holes to go.
Goosen, who had rolled to 8 & 7 and 12 and 11 wins in his first two matches, tried to fight back as he halved the 28th with a birdie and won the next with another birdie. However, the match was over when the duo halved the next.
'I remember watching this tournament when I was a youngster and I knew I wanted to be part of the World Match Play,' said Campbell, who advanced to the finals here for the first time. 'And now, finally, I'm a finalist. It's always been one of the dreams I wanted to fulfill.'
Cabrera did not trail in either of his first two matches. That quickly changed as McGinley birdied the second to take an early 1-up lead. However, McGinley bogeyed the third and Cabrera birdied No. 5 to take a 1-up lead of his own.
McGinley, who cruised to big wins over Thomas Bjorn and Luke Donald in his first two matches, caught fire around the turn. He birdied four consecutive holes from the ninth to grab a 3-up lead. But the Irishman bogeyed 13 and 16 as his cushion slipped to 1-up.
The two-time European Ryder Cupper birdied 17 and eagled 18 to take a 3-up lead to the afternoon session.
McGinley, the 14th seed, dropped a shot on the 21st hole, but was determined not to lose his lead. He matched Cabrera's birdie on the 22nd hole, then sank an eight-foot birdie putt on the next to go 3-up again.
The second-seeded Cabrera started to struggle from there. He missed a short par putt on the 27th and bogeyed the next to slide 5-down. The Argentine tried to right the ship as he birdied the 29th from 25 feet out.
McGinley drained a birdie putt on top of Cabrera's on the 30th hole. The Irishman came up short on the par-3 32nd and that led to a bogey. Nevertheless, he was 3-up with four holes to go.
Cabrera lost his tee shot out of bounds to the right off the tee on the par-5 33rd. McGinley found the short grass of the tee and knocked his second onto the left fringe.
The Argentine played his fourth from the left rough after his second tee ball missed the fairway left. Cabrera knocked his fourth on the putting surface, but it did not matter.
McGinley lagged his eagle putt to tap-in range and was conceded the birdie putt and the match.
'It's great to be in the final and will be even greater to win it,' said McGinley, who is also in the final for the first time. 'I don't want a second place. I feel I've played well again today against another world class player. I'll be the underdog again tomorrow, playing the U.S. Open champion so I'm going to have to play really well.'
McGinley and Campbell have never gone head-to-head in a match play event before, but were paired earlier this year.
'I played the first two rounds of the U.S. Open with him,' McGinley said of Campbell. 'I said to him on the 18th green after the second round, 'Michael, if you play like that you'll win this thing!' The next two days, sure enough, he did.'