Maria Jose Uribe shot her second consecutive 2-under 70 on Tuesday and is alone in second place at minus-4.
Isabelle Lendl, the daughter of tennis Hall of Famer Ivan Lendl, carded a 5-under 67 in the second round of stroke play and is tied for third place with Lindy Duncan and Mindy Kim, both of whom shot 70s on Tuesday. The trio is knotted at 3-under-par 141.
Harigae flew out of the gate with a 10-foot birdie putt at her first hole, the 10th. She added another birdie at 12, but dropped a shot at 13 when she drove into the rough and knocked her second into the tall grass as well.
Around the turn, Harigae soared up the leaderboard with four consecutive birdies from the 17th. She rolled in a breaking, six-footer for birdie at the fifth to reach 4-under par.
She took advantage of her length at the par-5 eighth which resulted in a tap-in birdie. Harigae got to minus-4 thanks to a six-foot birdie putt from below the hole.
'On some holes I was just thinking par, or 'OK, get out of there with a two- putt,'' said Harigae, who needed only 26 putts on Friday. 'I started getting dialed in.'
Harigae, a semifinalist in 2003, has had a great record in USGA events. She was co-medalist at this year's Women's Amateur Public Links Championship before getting knocked out in the quarterfinals.
The 16-year-old has more incentive to win than her place in the history books.
'If I win,' said Harigae, a four-time California state Women's Amateur champion, 'my mom said I can get a car. If I win the Women's Am, I get my choice.'
Elisa Aoki carded a 2-under 70 and is alone in sixth place at 2-under-par 142. Patty Chawalitmetha shot a 1-over-par 73 and has sole possession of seventh place at even-par 144.
First-round leader Joanne Lee struggled to a 4-over 76 and shares eighth place with Taylore Karle (72), Sally Watson (73) and Kristina Wong (74). That group is knotted at plus-1.
Fourteen-year-old MacKinzie Kline, who was granted the use of a golf cart because of a congenital heart defect, shot a 7-over 79 on Tuesday, but advanced to the match-play round at 7-over-par 151.
Dakoda Dowd, who became the youngest player to compete in an LPGA tournament earlier this year at the age of 13, managed a 3-over 75 and also came in at plus-7. Dowd played in the Ginn Clubs & Resorts Open in late April because her mother, Kelly Jo, is battling breast cancer and wanted to see her daughter play on tour.
There was a 10-girl playoff for the final eight spots in the match-play section of the tournament.
Madison Pressel, sister of LPGA Tour star Morgan Pressel, and Austin Ernst were knocked out of the tournament.
Ivan Lendl's other daughter, Marika, moved on to the match-play portion of the tournament.
Tuesday marks the end of the first two rounds of stroke-play qualifying. The top 64 scorers will then start match play Wednesday and the event concludes on Saturday with a 36-hole match play final.
Last year, In-Kyung Kim defeated fellow 17-year-old In-Bee Park to win the event, which has proven to be a springboard for success for LPGA talent over the years. Past winners of this championship include Nancy Lopez, Hollis Stacy Amy Alcott and Pat Hurst. Stacy was a three-time champion while Lopez captured this event twice.