D.J. Brigman shot a 3-under 68 in round two to move into second place at 7-under-par 135.
Dan Olsen (66) and Johnson Wagner (69) share third place at minus-6. Chad Collins and Glen Day each shot 68 in the second round and share fifth place at 5-under-par 137.
Langham flew out of the gate with a 3-foot birdie putt on the first. At the next, he dropped his approach within a foot of the cup to set up his second straight birdie at Le Triomphe Golf & Country Club.
After a par on the third, Langham got up and down for birdie at the fourth to move to 7 under. The 37-year-old drained a 20-foot birdie effort on the next to keep moving clear of the field.
Langham capped a run of three straight birdies as he sank a 25-foot putt for birdie on the seventh. He climbed to 10 under with a short birdie putt at the par-5 12th.
The two-time winner on the Nationwide Tour stumbled to a bogey on the 14th. Langham dropped another stroke at nine where he missed a 6-foot par saving putt.
'I am pleased,' said an understated Langham. 'It played tough again today with the cold and the wind. Fortunately I got off to a good start and made some putts early.'
Brigman played the back nine first and got on the board with a birdie on the 13th. However, he tripped to a bogey on the 14th after his ball plugged in a bunker.
The 29-year-old again traded a birdie for a bogey from the 17th to make the turn at minus-4. Brigman chipped to 4 feet at the par-5 first and sank that putt.
Brigman, the 2003 Permian Basin Charity Golf Classic winner, dropped a wedge 5 feet from the cup at the second and dropped in that putt for birdie.
He again chipped to 4 feet to set up birdie, this time at the fifth, to get within one of the lead. However, he closed with four straight par to remain there.
Matt Weibring, who shared the first-round lead with David Morland IV, struggled to a 1-over 72. He slipped into a share of seventh place at 4-under-par 138. He was joined there by Brian Rowell (69).
Morland was one worse, shooting 73 on Friday. He stands alongside Matt Kuchar, Deane Pappas, Phil Tataurangi, Kevin Durkin and Matt Hendrix at minus-3.
The cut line fell at 1-over-par 143 with 64 players advancing to the weekend. Among those making the cut on the number were defending champion Ryan Hietala and Kevin Stadler, who made his tour-best ninth straight cut.