The win was Axley's first on the Nationwide Tour, a circuit he did not even have status on at the start of the week. He became the 18th Monday qualifier to win in tour history and the third lefthander.
'Monday qualifying makes for a long week,' said Axley, who collected $81,000 for the win. 'You play practice rounds on Sunday, then qualifying on Monday just to get in the tournament.
'Just to be able to play golf each week without worrying about qualifying on Monday is a huge burden lifted off my shoulders. It gives me a place to play for the next two years.'
Troy Matteson shot a 2-under 69 in the final round and came in second at minus-12. Ryan Armour carded a 4-under 67 and finished in third place at 11-under-par 273.
Since rain washed out all play on Friday, Sunday featured 36 holes of action.
Axley was tied for the lead after Sunday's third round, but dropped a shot at the first hole. He atoned for the miscue with birdies at four, six, seven and eight to take a two-shot lead.
Axley birdied the 13th and 15th to almost put the tournament away. Unfortunately, he bogeyed the 17th hole and Matteson was one shot behind. Matteson bogeyed the closing hole, giving Axley the two-shot win.
'It was a long day and a hard day,' said Axley. 'Troy pushed me all day. I'm mentally and physically tired. This feels awesome. It is hard to put into words what this does for my career. It means everything.'
Matt Weibring shot a 4-under 67 and took fourth at minus-9.
Craig Bowden, who held the second-round lead, struggled in Sunday's third round with a 4-over 75. He rebounded in the final round with a 69 and shared fifth place with David McKenzie, who posted a final-round 68. The duo was knotted at 8-under-par 276.