Rose, who started on the back nine, is 5 under par through 16 holes of his second round and has a 7-foot birdie putt at the par-5 eighth hole. The Englishman stands at 17 under par, thanks in part to his 12-under-par 60 on Thursday, and is four clear of Tag Ridings.
The horn sounded Friday evening to suspend play for darkness, but it was a fog delay at the start of play on Friday that went over an hour and set the tournament back.
The remaining players will return to both the Palm and Magnolia Courses at Walt Disney World Resort at 9:00 a.m. ET Saturday morning to finish the round.
The plan is for the second round to be completed, then make the 36-hole cut and bring the players out in threesomes off both the first and 10th tees starting at 11:00 a.m.
Ridings shot a 6-under 66 at the Magnolia Course and is in at 13-under-par 131. Troy Matteson, who earned his first PGA TOUR victory last week in Las Vegas, fired a 7-under 65 at the Palm course and is in third place at minus-12.
Robert Damron posted a 7-under 65 at the Palm course and is tied for fourth place with Marco Dawson, who carded a 66 at the same venue. The pair is knotted at 11-under-par 133.
One day removed from having a 15-foot chance to become the fourth player in PGA TOUR history to shoot a 59, Rose took to the Magnolia Course with hopes of trying to pad his five-shot lead.
Rose began his second round on the back nine and wasted little time in extending his cushion. He two-putted from 45 feet for a birdie at 10, then ran home a 12-foot birdie putt at the 11th to reach 14 under par for the championship.
The Englishman parred his next four holes but returned to his birdie ways at the par-4 16th. Rose knocked his approach inside 3 feet and kicked in the short birdie putt. He made it two in a row at the 17th when his 12-footer found the bottom of the cup.
Rose parred 18 to make the turn at 4 under par for the round, but 16 under par for the tournament. He built himself a five-shot lead and the history books looked ready for some adjusting.
Rose found a fairway bunker off the tee at the first, but hit his second to 14 feet. He sank that birdie try and holed a 12-footer for birdie at the second to extend his lead to seven strokes.
At the par-5 fourth, Rose drove into the right rough and elected to lay up instead of trying to hit a 5-wood and possibly bringing a lot of trouble into the equation.
Rose played an 8-iron down the fairway, then hit a wedge too hard and landed in the back bunker. He had a difficult sand shot and blasted out to 30 feet. Rose missed the par putt for his first bogey of the tournament.
'I was feeling good and making birdies and possibly got a little too aggressive on that one,' admitted Rose, referring to his third shot. 'I could well have just hit the sand-wedge 10 feet short of the hole, but I just kept seeing the flag. Sometimes it happens.'
Rose missed the green at five, but got up and down for par. He parred six and seven and has 7 feet for birdie on the par-5 eighth.
'You have to come back with a completely fresh mindset, almost forget about the day before. That's what I try to do,' said Rose. 'I try to approach it with the same attitude I had the day before, which is go out there and obviously play one shot a time and just know I was playing well.'
Jerry Kelly (68), Richard S. Johnson (70), Woody Austin (66), Joe Durant (65) and Bubba Dickerson (68) are knotted in sixth place at 10-under-par 134. Johnson was the only player of the group who played his second round on the Magnolia Course.
Defending champion Lucas Glover is on the course at 9 under par for the championship.