Jason Dufner is alone in second place at minus-11 after a second-round 66. Blaine McCallister also shot up the leaderboard as he carded a 7-under 64 to get to 10-under-par 132.
Uresti began his round on the back nine of the Glenmaura National Golf Club. He opened with a birdie at the par-5 10th. He followed that up with a birdie at the par-3 11th and made it three straight when he birdied the 12th.
The former Texas Longhorn made it four birdies in five holes when he birdied the par-5 14th. Around the turn, Uresti moved to minus-9 with a birdie at the par-4 third.
Uresti got to double-digits under-par when he birdied the par-4 sixth. He closed out his round in fine fashion with birdies on each of his final two holes to tie the course-record of 8-under 63 set last year by Don Reese.
'It's been quite a while since I've made that many birdies,' said Uresti, who is searching for his first win since the 1994 Shreveport Open. 'I'm a little bit surprised I guess.'
Uresti had to make a big change in the offseason with his putting.
'Everyone was calling me 'slo-mar' last year and I figured I needed to speed things up,' said Uresti, who had 23 putts during his round. 'One of the officials timed me at 57 seconds for one of my putts last year. I was stunned. Now I've got it down to 10 and that's helped a lot.'
Dufner, who began his day one stroke off the lead, opened with a pair of pars before running off four consecutive birdies from the par-4 12th. He was unable to keep his momentum as he bogeyed the par-4 17th.
On the front side, Dufner posted two bogeys and four birdies en route to a 5-under 66.
McCallister started his day four strokes behind overnight leader Lucas Glover. McCallister struggled out of the gate with a bogey at the par-3 second. He made up for that mistake with back-to-back birdies from the fifth.
Around the turn, McCallister really caught fire. He birdied the 10th to get to minus-5. He then turned it on with an eagle at the 12th. He followed that up with a birdie at the 13th and another at No. 14. He capped his stellar round with a birdie at the par-4 16th.
Bill Glasson stands alone in 4th place at 9-under-par 133. Charles Warren, Stephen Gangluff and Zach Johnson are one stroke further back at minus-7.
Glover stumbled to a 3-over 74 and stands at 4-under-par 138 alongside defending champion Gary Hallberg and 10 other players.
The cut line fell at 2-under-par 140. Among those not making the weekend was Jason Hill, the 2001 winner of the NE Pennsylvania Classic.