Chris Sessler carded his second straight 5-under 67 to take second place at 13-under-par 203. Scott Petersen is one stroke further back at minus-12, while David McKenzie, Tyler Williamson and second-round leader Jody Bellflower share fourth place at 11-under-par 205.
Wetterich scorched Willow Creek Country Club's five par-5s. At the par-5 first, he dropped a 7-iron 10 feet from the cup and drained the eagle putt to quickly move to minus-10. Two holes later, Wetterich birdied the par-5 third.
After dropping a shot at the eighth, Wetterich birdied the par-5 10th to get back to 11 under. He parred the 12th, his lone par on a par-5 in the third round, but he came right back to birdie No. 13.
Wetterich dropped in the fourth birdie of his round at the 16th. At the par-5 17th, the 2003 Louisiana Open winner drained his second eagle of the day, from 15 feet out, as he played the five par-5s in 6 under on Saturday.
'If you can hit it in the fairways on the par-5s here, you'll have an iron in your hand and sometimes it'll be a short iron,' Wetterich said. 'You walk away mad if you make par or bogey. You have to take advantage of the par-5s here.'
Wetterich hit 16-of-18 greens and 12-of-13 fairways during his round, but he also had a solid day with the putter.
'I made a lot of putts that I should have made and made a couple of good putts that were 50-50 to keep my round going,' said Wetterich. 'It's tough out there and the greens are getting firmer and they're getting faster. If you miss the green, it'll cost you for sure.'
Sessler opened with six straight pars before bogeying the par-3 seventh. He atoned for that mistake with a birdie at the ninth. Around the turn, he eagled the 12th and birdied the 14th to get to 11 under. He closed with back-to-back birdies from the 17th to move into second place.
Petersen opened with a birdie at the first and an eagle at the third to climb to 7 under. He picked up birdies at Nos. 9, 12 and 14 to get to 10 under. Like Sessler, Petersen closed with birdies at the 17 and 18 to move into third place.
'I was thinking about how bad my numbers have been all year on Saturday and Sunday and I was trying improve on that,' Petersen said. 'I was trying to get a little different mindset and relax a little bit more.'
Ryuji Imada, the Charity Pro-AM at The Cliffs winner, fired a 65 to move to 10-under-par 206. He is joined there by Doug Barron, Todd Rose and Bubba Watson.
Rheem Classic winner, Franklin Langham, joins D.A. Points a two-time winner this year at 9-under-par 207. They are joined there by first-round co-leader Garrett Clegg and Scott Gutschewski.
Jimmy Walker, another two-time winner this season, leads a group of eight players at 8-under-par 208.