Wie, whose lone title came at the 2003 U.S. Women's Amateur Public Links, grabbed the early lead when she birdied the par-5 fourth. Park battled right back to win the sixth with a birdie.
Park moved 1-up as Wie faltered to a bogey at the seventh. Park stumbled to a double-bogey at the very next hole to square the match.
The Hawaiian regained a 1-up lead with a par at the par-3 11th. Wie extended her lead to 2-up as Park bogeyed the par-4 13th. Park turned it on down the stretch.
Park birdied the par-four 16th to get it to 1-down. Wie tripped to another bogey at the 17th to square the match heading to the final hole. Park putted to within inches of the cup from 60 feet away and was conceded her par. She claimed the match when Wie three-putted for bogey from 15 feet on the 18th.
'I gave her that match tied up in a box with a pretty pink ribbon,' said a disappointed Wie. 'I wish I didn't have to lose with a three-putt green. I thought I hit the first putt good. I didn't think it was going that far past. It's really disappointing, but it's been a really good week.'
Park, however, wasn't as successful in her afternoon match. Park was knocked off in the third round by Morgan Pressel, 3 and 2. Pressel jumped out to a quick 2-up lead with birdies at each of the first two holes.
Pressel stumbled to bogeys at the fifth and seventh to square the match. She fought right back to birdie the eighth and regain a 1-up lead. Another birdie at par-three 11th moved Pressel to 2-up and she stretched her lead to 3-up with a birdie at the par-5 12th.
Park cut her deficit to 2-down with an eagle at the par-5 14th. However, Pressel birdied the 15th to move 3-up and the match was over as they matched pars on the 16th. Pressel moves on to play Sarah Huarte, who downed Julieta Granada, 3 and 2, in the quarterfinals.
'I wanted to play Wie,' said Pressel, who downed Wie in the third round of the 2003 U.S. Girls Junior. 'I wanted to beat her. I think if I had beaten her again, people would have started talking.'
In one on the top matches of the afternoon, 2004 Curtis Cup player Paula Creamer claimed a 2 and 1 win over Brittany Lincicome. The pair swapped birdies at the second and fourth, then again at eight and nine to make the turn all square.
Creamer, who knocked off Hsiao-Ching Lu in the second round, stumbled to a bogey at the 11th to give Lincicome her final advantage. Creamer squared the match when Lincicome bogeyed the 13th. Creamer picked up birdies on the 14th and 16th to go 2-up. Each player bogeyed the 17th to close the match. Creamer will take on Diana Ramage in the quarters.
'It was a good match,' said Creamer. 'She missed several short putts at the beginning and it set the pace of the match.'
Ramage needed 38 holes to win her two matches Thursday. She knocked off 2004 Curtis Cup member Elizabeth Janangelo, 1-up in 19 holes in the second round and beat Karen Dennison by the same score in the third round.
After winning her first two matches by an identical 5 and 3 score, Sun-Young Yoo pounded Margaret Shirley, 7 and 5, in the third round. Yoo will match up against Amanda McCurdy, a 1-up winner over Grace Woo, in the quarterfinals.
Jane Park, who cruised to a 6 and 4 win over Kim Shin in round two, hung on to down Mina Harigae, 1-up in round three. Park will square off against Beth Allen in the quarterfinals. Allen moved on with a 1-up win over Jenna Pearson.