Wendy Ward posted a 7-under-par 65 to share second place with Seon-Hwa Lee. Karen Stupples, the 2004 Women's British Open champion, is one stroke further back at minus-6.
'That's always my biggest problem, not really starting off on the right foot,' said Wie of her round that included six birdies and a bogey. 'I feel very proud that I actually started well. It's a three-day tournament and starting well is very important.'
Ochoa, who lost in a playoff to Joo Mi Kim at the SBS Open at Turtle Bay last week, started her round Thursday on the back nine at Ko Olina Golf Club. She stumbled to a bogey on the par-3 12th.
The Mexican rebounded with a vengeance though. She eagled the par-5 13th after knocking her 3-wood to 10 feet, then birdied the par-5 14th to get to minus-2. Ochoa rolled in a 25-foot birdie attempt on 15 and made it three straight as she birdied the par-3 16th.
Ochoa picked up another birdie, from 18 feet out, at the par-4 18th to make the turn at 5 under. The 24-year-old made it two in a row as she got up and down for birdie on the first. Ochoa collected birdies on the fifth and seventh to get to minus-8. She closed with two pars to hold the outright lead.
'Well, I'm very happy with the way I played,' said Ochoa. 'It was one of my goals just to have a good first day to make sure that I have a chance to win a tournament on the weekend. I got off to a good start last week and was really focused today. I feel great.'
Ward was playing right in front of Ochoa, however Ward's back nine was not as good. She managed birdies on 13 and 17 to head to the front side at minus-2.
The 32-year-old birdied the first. Ward then collected back-to-back birdies from the third and again from the sixth to jump to minus-7 and a share of second.
Lee flew out of the gate with birdies on each of her first two holes, Nos. 10 and 11. She eagled the 13th to move to minus-4. The Korean sank another birdie try on 14.
The 20-year-old faltered to consecutive bogeys from the 15th to slide back to minus-3. Lee got one stroke back with a birdie on the 18th. Around the turn, she birdied the first to get back to 5 under. Lee notched birdies on the fifth and eighth down the stretch to finish at minus-7.
Michele Redman, Nicole Perrot and Heather Young also share fifth at 5-under-par 67.
Japanese sensation Ai Miyazato, who won the LPGA Tour Qualifying School by 12 strokes, carded a 4-under-par 68. She was joined there by Beth Bader, Karin Sjodin, Liselotte Neumann, Nicole Castrale, Jeong Jang and Sae-Hee Son. Kim, last week's winner, stands at minus-3.