The tournament ends with 10 singles matches Sunday.
Europe won three and halved one of the four greensomes to open an 8 1/2 -5 1/2 lead, before Britain & Ireland won three of the afternoon foursomes.
Scottish Open champion Gregory Havret had a hole-in-one at the 189-yard seventh with a 4-iron in the morning as he and Raphael Jacquelin beat Nick Dougherty and Graeme Storm of Britain & Ireland 2 and 1.
But Dougherty and Justin Rose snapped the French pair's three-match winning streak 2 and 1 in the foursomes. Jacquelin and Havret bogeyed three of the last five holes.
'It's a shame. We played great for three rounds but this afternoon was a little tougher,' Havret said. 'The difference was their short game. Justin holed a chip on 16 and I didn't hole a putt on 17 to stay alive.'
Colin Montgomerie went down to his third defeat in three matches when he and Storm lost 3 and 2 to Gonzalo Fernandez-Castano and Robert Karlsson in Europe's only win in the afternoon.
Britain & Ireland then won the last two foursomes. Simon Dyson and Oliver Wilson won three of the first five holes and were never caught as they beat Peter Hanson and Soren Hansen 3 and 2.
Dyson and Wilson, beaten in the morning greensomes by the same pair, were determined to win.
'We came out firing and I holed a 20-footer at the first and third, and from six feet at the fifth,' Dyson said.
Then Bradley Dredge and Phillip Archer won on the 18th by two holes against Markus Brier and Miguel Angel Jimenez of Europe when Brier hit the second shot into the lake beside the green.
Britain & Ireland have won the trophy on three out of four occasions.
Montgomerie and Storm were one up at the turn but their opponents made four birdies on the back nine.
Montgomerie will lead off the singles for Britain & Ireland against Karlsson, while Rose -- the team's highest-ranked player at No. 13 -- will be held back until the last match against Jimenez, Europe's most experienced player.
In the morning, Fernandez-Castano, a late replacement for the ailing Thomas Bjorn, joined with Karlsson to upset Rose and Paul Casey 3 and 1.
The winners birdied five successive holes around the turn and added an eagle two holes later.
Bjorn's stomach upset has cleared up and he will likely play in the singles.
Brier and Ilonen birdied the last two holes to snatch half a point from Dredge and Archer who led by two with two holes left.
But Ilonen holed from 25 feet for birdie at 17 and Brier from 20 feet at the last to split the match.