Johnson and Poulter grabbed the lead with birdies on their first four holes and never looked back, finishing at 30-under 186 at Tiburon Golf Club. Clarke and McDowell (59) never got closer than two strokes.
The two teams passed second-round co-leaders Jerry Kelly and Steve Stricker (64), and Fred Funk and Kenny Perry (66).
Kelly and Stricker, the defending champions, tied for third at 26 under with Chris DiMarco and Anthony Kim (61).
The 12 teams in the tournament hosted by Greg Norman played modified alternate shot on Friday and better ball on Saturday at Tiburon Golf Club.