Kaymer, the recent rookie of the year, had nine birdies for a 13-under 131 total. Francois Delamontagne shot 66 and Benn Barham 68 to share second. Henrik Stenson (68) shared fourth with four others, another stroke back.
Miguel Angel Jimenez, the leading European money-winner, struggled to a 75 and missed the 1-under cut. John Daly (72), who had three straight back nine bogies, also missed the cut.
The 23-year-old Kaymer won his first title at Abu Dhabi in January and is touted as one of Europes most promising young players'and the German successor to two-time Masters champion Bernhard Langer.
Hes attempting to become the first German winner of the event in its 20-year history.
Langer shot 72, which left him well back. On the sixth hole, after Langer had an eagle and Kraymer had a birdie, the two high-fived each other.
It was a pleasure to watch him, Langer said. I dont think theres any limits for him if he keeps that up. I told him, Youre very aggressive, but youre smart at the same time, like Tiger Woods is or Phil Mickelson.
Paul Casey (68) and Retief Goosen (69) and David Howell (69) remained near the top of the leaderboard, seven shots behind Kaymer.