Mickelson, the No. 2 player in the world and a two-time winner on the PGA Tour this year, joins a four-man field that includes two-time defending champion Stephen Ames. The other two spots will be filled out this summer, although an invitation has been offered to Sergio Garcia as winner of The Players Championship.
The LG Skins Game, which began in 1983, will be played Nov. 29-30 at Indian Wells Golf Resort.
Mickelsons last appearance was in 2003, when he finished third with five skins and $170,000 behind Fred Couples and Annika Sorenstam.