Martin had a 69 on the Crooked Cat course at Orange County National and had a one-shot lead over Driscoll, who had a 66 on the same course. Martin was at 270 through four rounds of the six-round tournament.
The top 25 will earn PGA Tour cards for 2011.
Billy Mayfair posted his fourth straight round in the 60s with a 68. He was tied for fourth, only four shots out of the lead. The difference between Martin and the final spot was eight shots.
Brett Waldman, the caddie for Camilo Villegas, had a 72 and was tied for 59th, three shots behind the cutoff. After the top 25, the next 50 get cards on the Nationwide Tour.