'Oh, man!' Moore said. 'It's just amazing.'
Moore finished with a 12-under 276 total on the Crosswater Golf Club course for a four-stroke victory over Georgia's Chris Kirk (68) and Wake Forest's Kyle Reifers (72).
Oklahoma State, under first-year coach Mike McGraw, shot a 5-under 283 in the final round -- with the top four scores from the five-player squad counting in the total -- to finish at 9-under 1,143 -- three strokes ahead of Florida.
A day after periodic downpours vexed the players, it was partly cloudy and dry on the 7,630-yard course just south of Bend.
Florida shot a 10-under 278 to finish second. It was a remarkable turnaround for the Gators, who finished the third round at 10 over.
'Sometimes you get mad and you feel sorry for yourself. And sometimes you get mad and you're not going to take it anymore, and I think that's where we were,' Florida coach Buddy Alexander said.
Washington did just the opposite. After taking the lead into the final round with a 7-under 857 total, the Huskies tumbled off the leaderboard with a 13-over 301 to tie for ninth at 6-over 1,158.
Minnesota and Wake Forest tied for third, four shots behind Oklahoma State.
Moore, coming off consecutive victories in the Perry Maxwell Invitational in Ardmore, Okla., and the NCAA Central Regional in Cleveland, grew up in Vancouver, Wash., just across the Oregon border from Portland.
At the 2001 Oregon State Amateur, Moore won six matches to become the youngest champion in the 99-year history of the event.
After coming out of the scorer's tent as the national champion, Moore hugged his father, Ed.
The top-seeded Oklahoma State were making their 60th consecutive appearance in the championships, the longest active streak.