Canizares, the son of Champions Tour player Jose Maria Canizares, beat Matthew Rosenfeld (Texas) 3 and 1 after teaming with fellow Spaniard Pablo Martin (Oklahoma State) to edge Jeff Overton (Indiana) and Michael Putnam (Pepperdine) 2 and 1 in a best-ball match on Whistling Straits' Irish Course.
The Ryder Cup-style event for players attending U.S. colleges will end Thursday with four alternate-shot and eight singles matches.
The victories gave Canizares eight wins and eight points in three Palmer Cup appearances, both of them career records. He is trying to help Europe win the competition for the third straight time.
'Of course we want to win. They're really good players and it would be great to win, but it will not be easy,' Canizares said.
The United States leads the series 4-3-1.
In singles play, New Mexico's Spencer Levin overcame a three-hole deficit to halve his match with Europe's Rhys Davies (East Tennessee State). Levin birdied the par-5 18th after Davies took a one-hole lead with a birdie on No. 17.
'It was a tough match,' Levin said.
Levin also teamed with John Holmes (Kentucky) to beat Davies and Steve Tiley 6 and 4 in the morning best-ball matches.
In the other best-ball matches, Europe's Scott Jamieson (Augusta State) and David Skinns (Tennessee) beat Rosenfeld and Matt Every (Florida) 3 and 2, and Americans Ryan Blaum (Duke) and Roberto Castro (Georgia Tech) birdied the final two holes to edge Alex Noren (Oklahoma State) and Kalle Edberg (Augusta State) 1-up.
'Every point is important,' Blaum said. 'We played with a lot of heart.'
In the other singles matches, Every beat Skinns 4 and 2, Holmes defeated Tiley 3 and 2, Overton halved his match with Martin, Putnam beat Jamieson 5 and 4, Noren defeated Blaum 5 and 4, and Edberg beat Castro 3 and 1.
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