The 45-year-old Pampling had a 20-under 195 total. He opened with consecutive 9-under 63s at The Reserve at Lake Keowee and Green Valley Country Club to take a four-stroke lead.
''It's still foot down and I'm sure second is closer than it was yesterday,'' Pampling said. ''You can't take your foot off the accelerator. It's foot down the whole way and you just take advantage of good shots and I didn't do that today.''
Mark Blakefield and Kelly Kraft were tied for second. Blakefield had a 64 at Green Valley, and Kraft shot a 66 at Thornblade Club, the site of the final round.