The 18-year-old American birdied three of the first five holes and made par the rest of the way at the Golfpark Gut Haeusern, north of Munich.
I felt I was a little bit rusty. But I am happy with how I played today, said Wie, who is hoping to gain some confidence after playing just two tournaments in the United States this year.
I feel I can do a lot. I left a lot out there on the par-5s.
Its Wies first appearance in a full Ladies European Tour field after receiving a sponsors invitation to play in the event.
Reis had eight birdies, including at the last two holes, for a bogey-free round of 64.
Lora Fairclough of England, who won here in 1998, and Frances Jade Schaeffer were tied for second, two shots behind Reis. Three players had 67s to sit a stroke further back.
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