Shiho Oyama of Japan led after the first round with an 8-under 64 on the Champions course at LPGA International.
Wie played on the more difficult Legends course and rarely was in trouble while hitting only four drivers. Her lone bogey came on the 14th hole, which she three-putted from 25 feet for bogey.
She was in a tie for sixth after the first of five rounds. The top 20 earn full status on the LPGA Tour next season.