The 17-year-old Wie had a 7-over 149 total at Royal Mayfair, leaving her 15 strokes behind the leaders with about a quarter of the field still playing the second round.
'I missed a couple of crucial putts here and there and a couple of shots didn't go the way I wanted to,' said Wie, who had five bogeys and two birdies Friday. 'It's frustrating to see my score was high when I don't feel I played that bad.'
Juli Inkster (66) and Shi Hyun Ahn (67) had the clubhouse lead at 8-under 134. Top-ranked Lorena Ochoa (65), Kimberly Hall (67) and Laura Diaz (70) were 7 under.
Wie, slowed this year by wrist injuries, also missed the cut two weeks ago in the Women's British Open at St. Andrews, shooting 73-80. The week before the Women's British Open, she tied for 69th in France in the Evian Masters, shooting 73-71-84-76 in her first start since withdrawing from the U.S. Women's Open in June because of a sore left wrist.