Stricker completed the final three holes of his second round Saturday morning, ending with a birdie on the par-5 18th. The veteran carded rounds of 69 and 72, but with ultra-low scoring at TPC Louisiana he still fell two shots short of the cut line, which was projected at 5-under 139.
Stricker was making just his second start since undergoing hip surgery in December. He made the cut earlier this month at the Masters, where he finished tied for 28th. This is Stricker's first missed cut since the 2012 Players Championship.
Stricker's consecutive made cuts streak became tops on Tour last month, when Adam Scott missed the cut at the Valspar Championship. The top active streak now belongs to Matt Kuchar, who made his 22nd consecutive cut last week at the RBC Heritage.
Stricker's was not the only streak to end in New Orleans. At 4 under, Rickie Fowler missed his first cut since the Memorial last year, ending a run of 17 straight made cuts that was tied for third behind Stricker and Kuchar.
Stricker has played a limited schedule in recent years, and earlier this week the 48-year-old admitted he was still recovering from his hip injury.
"I still need to be somewhat cautious," he said. "I'm going to play probably week-on, week-off, week-on, week-off schedule into June and see how it goes from there."
At No. 74 in the OWGR, Stricker is not qualified for next week's WGC-Cadillac Match Play Championship, and he is also not exempt for the U.S. Open. His next start is expected to be at The Players Championship.