Weir was 6 over after 10 holes at PGA National before calling it quits. This is his second withdrawal in as many weeks, as he also withdrew from the Northern Trust Open after 25 holes because of the same elbow injury.
Weir, 44, has had chronic issues with his right elbow, and the Canadian had surgery in 2011 to repair a damaged tendon. His T-21 finish at the CIMB Classic in November is the only time this season he has completed four rounds of an event, as Weir now has two withdrawals to go along with six missed cuts in nine starts.
The tournament also lost another major champion when Louis Oosthuizen withdrew prior to the opening round because of neck pain. Oosthuizen, who was set to make his first PGA Tour start of the year, was instead replaced in the field by Mark Hubbard.