Andrades 5-under performance Thursday in the SEI Pennsylvania Classic was one stroke lower than Kenneth Staton and J.J. Henry.
Matthew Goggin and Donnie Hammond are a shot further removed.
Andrade was tied for second after opening in 66 last week at the Bell Canadian Open, and then moved to co-leader after round two. However, he stumbled on the weekend, shooting 70-73 to finish tied for 12th.
This time hes out front from the start.
Andrade made his way around the Waynesborough Country Club in bogey-free fashion, birdieing all three of the par-5s the course has to offer.
The 15-year PGA Tour veteran has won four times on tour, but hasnt stepped into the winners circle since the 2000 Invensys Classic at Las Vegas.
'I was fighting my swing all summer long and playing some horrible golf,' Andrade said. 'You've got to find a way to get it back. I'm a classic fighter, I guess.'
Henry started on the back nine and turned in 4-under, but played the front nine in even par.
Henry entered the week 104th on the money list with $514,938 in 28 events.
'I joked with my caddie two weeks ago in Vancouver that I had as much money then as I did the same time last year when I went on to make over a million dollars and have a great rookie year,' he said. 'So I can play more aggressively these last seven or eight weeks and give myself a chance.'
Staton used three birdies in a four-hole stretch to propel him up the leaderboard. After a three-putt bogey on 17, he finished with a birdie on 18.
'I lost a little concentration on 17,' he said. 'It's really my own fault. I just told myself to forget it and not bogey 18.'
Full-field scores from the SEI Pennsylvania Classic