Burke, 41, the wife of 1956 Masters champion Jackie Burke Jr., had an even-par 142 total on the Long Cove Club course in the tournament for players 25 and older.
Defending champion Kathy Hartwiger, 37, of Birmingham, Ala., finished three strokes back at 145 after a 74.
Two-time winner Carol Semple Thompson, 54, of Sewickley, Pa., shot a 77 to advance to match play with a 151 total.
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