Zoeller, who turned 50 on Nov. 11, is making his debut on the Senior Tour. Irwin is the defending champion.
All 18 holes will be played Saturday, Jan. 26; however, ABC-TV will broadcast 12 holes Saturday and the final six holes Sunday.
Irwin won the 2001 edition with seven skins and $320,000. He won the final six skins and $180,000 with a birdie on the first extra hole. Nicklaus finished second with 10 skins and $260,000. Ironically, had Nicklaus missed a four-foot birdie putt on the 18th hole, he would have won the event.
A Nicklaus miss on 18 would have given Gary Player six skins and $180,000 and the Golden Bear would have been the champion. Instead, Nicklaus made the putt to halve the hole and force the playoff.
'I never miss on purpose,' Nicklaus said, though, upon making the putt, he quipped, 'I want to stab myself.'
Irwin is making his fourth appearance in this event. Palmer is playing in his 14th Senior Skins Game and Nicklaus is making start No. 12.
Zoeller played in three regular Skins Games. In his first appearance in 1986, he was blanked on the first day, and then won all nine skins on Sunday to win the title with $255,000. The following year he won a then-record 14 skins and $310,000.
The four men have combined for 212 titles on both the PGA and Senior Tours, and 49 total major championships.
The $600,000 total purse is broken down to $20,000 for each of the first six holes, $30,000 for each of the middle six holes, $40,000 for Nos. 13-17, and $100,000 for the 18th hole. Unlike the last regular Skins Game ' where Greg Norman won all 18 skins and $1 million ' players do not need to validate a skin on the following hole.