Goosen, who led after Day 1 with a beautiful 64, fired a flawless 65 Saturday to jump to 13-under-par 200 for the tournament.
The South African and winner of this years Scottish Open and United States Open leads by a stroke over Niclas Fasth (66) and Sergio Garcia (68), while Gary Emerson (66) is two back at 11-under.
Should Goosen hold on for victory, he will become the first player to win back-to-back titles at this event since David Graham did so in 1981-82.
If he plays anything like he did on Saturday, he should not have a problem.
Goosen began immediately with birdies at the first and second holes and proceeded to rattle in two more at Nos. 5 and 8 for an outward half of 32.
Two more red numbers at the par-4 11th and 13th holes, and he sped ahead of the many formidable challengers.
Yesterday was a bit of a struggle, but today was much better, said the 32-year-old in reference to his Day 2 score of 71. I managed to keep the ball well on the golf course and holed a few good putts, so I cant ask for much more than that.
While Goosen indeed couldnt ask for more on the day, the same might be said for his year. Leading the Order of Merit for the European Tour, he looks a good bet to hold his position come seasons end.
Likewise, Garcia is also having a breakout year, although his successes have come strictly in America.
The winner of this years MasterCard Colonial and Buick Classic, a Garcia-victory on Sunday would mark his third of the season as well.
Coming off a fine 65 on Saturday, the young Spaniard might have joined or even eclipsed Goosen entering the final round had it not been for bogies at the 14th and 18th holes.
Nevertheless, a sandwiched birdie at the par-4 17th has him right in the mix for Sundays finale at Saint-Nom-La-Breteche.
Full-field scores from the Trophee Lancome