Kane took the prize last year when she beat out Mi Hyun Kim on the first hole of a sudden death playoff. It marked the second of three wins in a breakout 2000 season, and followed nine runner-up finishes in years prior.
This year, the Canadian-born pro has already chalked up five top-5 finishes, one of which came as a win at the LPGA Takefuji Classic .
She will need to beat out a star-studded field this week if she is to defend, however.
Last weeks winner of the Women's British Open , Se Ri Pak is scheduled to compete. She will be joined by Annika Sorenstam, Karrie Webb, Dottie Pepper, Grace Park and Laura Diaz.
They will all be gunning for the $150,000 first-place prize of the $1 million purse.
The New Albany Country Club is par-72 layout which measures 6,279 yards. Last year, the event was called the New Albany Golf Classic.