Moodie made last years edition the first win of her young career, as she posted rounds of 68-68-69-203 (-10) for a two-stroke victory over Pat Hurst and Grace Park.
The triumph came after finishing runner-up on three different occasions over her last two seasons.
While she has not yet collected her second, the 28-year-old from Glasgow, Scotland has come close on several occasions.
She finished second at this years Nabisco Championship, with only Annika Sorenstam playing better golf. She also recorded a fifth-place finish in Mays Champion's Classic.
Last week, Moodie finished in a tie for 64th with a four-day total of 10-over-par 294.
Nevertheless, the Bay Course at the Marriott Seaview Resort suited her game just fine last year, and she will be hoping for the same results this time around.
Others who will be present for the ShopRite are Dottie Pepper, Laura Davies, Lorie Kane and Pat Hurst.
Last weeks winner of the McDonalds LPGA Championship ' and the now-youngest winner of the career Grand Slam ' Karrie Webb will take the week off.
So too will five-time winner in 2001 Sorenstam.
The ShopRite boasts a total purse of $1.2 million, with $180,000 going to the victor. The Bay Course at the Marriott Seaview Resort plays to a par of 71 at 6,051 yards.