She leads by one stroke over Nancy Scranton, Brandie Burton, Jean Bartholomew, Emilee Klein and long-hitting Laura Davies, while defending champion Meg Mallon and Laura Diaz are just two shots back.
Lindley, a recently-turned 29-year-old, is searching for her first win in six years on the LPGA Tour.
Her best finish to date is a second-place showing at the 99 City of Hope Myrtle Beach Classic, and her best performance this year is a tie for sixth at the season-opening YourLife Vitamins LPGA Classic.
She is hoping that will improve a bit this week.
Lindley got the rock rolling early in her round Thursday, dropping birdie putts at Nos. 3 and 4 before giving a stroke back to par at the par-4 6th.
She rebounded rather quickly, however, birdying the eighth and ninth, and then carding additional red numbers at 12 and 17 for 67, her low round of the year.
Just one back of Lindleys pace is a woman who HAS won on the LPGA Tour. Problem is, she hasnt been doing all that well in recent times.
Laura Davies has taken 19 titles on the womens circuit, including four major championships. Yet, the big Englishwoman has only made one top-10 finish this 2001 season, and has had much more success in missing cuts than anything else. In ten events this year, she has not played on the weekend five of those times.
Yet, she too carded her best round in some three months, posting 68 at Locust Hill on Thursday, and barring disaster Friday, should hang around for the weekend.
Among a large group of players tied for ninth at 2-under are Becky Iverson, Pearl Sinn and Liselotte Neumann.
Dottie Pepper shot an even-par round of 72.
Full-field scores from the Wegman's Rochester International