The 45-year-old O'Meara rolled home a three-foot birdie putt on the par-3 15th that was worth three skins and $210,000.
He added another birdie at the par-3 17th that was good for one skin and $70,000 which pushed his total to eight skins and $405,000.
'Sometimes when you fly low under the radar, good things happen,' said O'Meara about the much publicized match-up between Mickelson and Woods.
Mickelson tied with Couples for fewest Skins with three, but a birdie at the closing hole was worth $200,000 and pushed his two-day total to $300,000. It was the left-hander's first visit to the Skins Game and he avoided being shutout with his tap-in putt at the par-5 18th.
'Wouldn't it be cool if we all won a skin today?' Mickelson jokingly asked Tiger as they strolled to the 18th, knowing full well he was the only one yet to pick up a skin.
Couples, a three-time champion at this event, collected two skins Sunday to avoid last place, which strangely enough went to Woods.
Tiger, who has yet to win in his four attempts at the Skins Game, could only muster one skin, that coming on a 18-foot eagle putt at the first hole on Sunday. It was his fourth skin on the weekend.
'That's better than I usually do,' Woods said, referring to the fact that he had won only five skins total in his previous three trips combined.
Results from the 2002 Skins Game