Grimes, 41, the 1998 winner, was playing her first round in a national event since having back surgery a year ago. Burke, 41, the 1997 Women's Amateur runner-up, is the wife of 1956 Masters champion Jackie Burke Jr.
Defending champion Kathy Hartwiger, 37, of Birmingham, Ala., and Tracy Welch, 32, of Boston, opened with 71s on the Long Cove Club in the event for players 25 and older.
The low 64 players after the second round of qualifying will advance to match play.
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