Slocum fired a bogey-free 64 to earn a share of the lead at Fox Den Country Club in Knoxville, Tenn.
At 8-under-par, Slocum is tied with Sonny Skinner, who had nine birdies and one bogey on Thursday.
Slocum, 27, has a win and a third-place finish in his last two starts. He captured his first-career tour victory at the Greater Cleveland Open, where he also opened in 64; and then came just shy of recording back-to-back wins at last weeks Dayton Open.
Slocums recent surge has him in 5th place on the 2001 money list. Thursday, beginning at the 10th, he made the turn in 6-under-par 30. He birdied both front-nine par-5s to complete his scoring.
Full-field scores from the Buy.Com Knoxville Open