Coming off a course record 64 in the third round, Sorenstam concluded her fine weeklong play at Angus Glen, shooting a 69 to finish at 16-under-par 272.
She finished two shots ahead of Kelly Robbins, who carded a 71 Sunday to end at 14-under, and four ahead of Women's British Open champion Se Ri Pak (68) and Canadas own Lorie Kane (70).
Beginning the day tied for the lead with Robbins, Sorenstam made the charge right off the bat, rattling in a birdie at the first and adding two more at the fifth and ninth for an outward half of 33.
Two more birdies on the back nine at Nos. 13 and 14 saw Sorenstam move seven ahead of Robbins, who had fallen to minus-12 with bogies at the 7th and 12th.
Robbins would rebound, however, closing with three birdies over her final four holes for a 71, but it was just too much ground to overcome, and even Sorenstam-bogies at Nos. 17 and 18 wouldnt allow for a change-of-leader.
Click here to see Annika Sorenstam's scorecards.
In 19 events this year, Sorenstam has now won six times in 2001. In addition to that, she has recorded an additional six top-5 finishes, four of which were runner-ups.
One of her wins came by way of the Nabisco Championship ' her third career major ' and she also shot a record 59 at the Standard Register PING, which was part of a streak consisting of four wins in a row.
Sorenstams best year leading up to this was 1997, when she also won six times, none of which were majors.
She is coming off a 2000 season that saw her take five titles, but wind up behind Karrie Webb, who won seven times.
Their rivalry have been growing all season, but Sorenstam is looking to pull ahead with this latest win.
Webb has won two times this season, both of them majors. This week, she finished in a tie for 15th at 6-under.
Full-field scores from the Bank of Montreal Women's Canadian Open