At 5-under-par, the trio leads by a shot over five others in Newport, Wales, where sunnier skies Friday saw the field finally complete Round 1 after Thursdays washout.
The second round is scheduled to be played on Saturday, while the final two rounds will be held Sunday following a cut of the low-50 and ties.
For the three players at the top, however, the time was the present on Friday, and each took advantage of good scoring conditions with six birdies against just a single bogey.
For McGinley, four of those six birdies on the day came over the closing six holes, and the round couldnt have come at a more opportune time, as the Irishman is currently 10th on the Ryder Cup points standings.
In his tenth full year on the European Tour, the 34-year-old is bidding to qualify for his first career Ryder Cup.
All I can do is play my own game and let everyone else look after theirs,' said McGinley following his round. 'I am in tenth position but I know I cant defend the position. I have got to accelerate from here over the next four weeks.
For Lawrie and Orr, however, the clock is ticking for Septembers big game, as each man sits at 25th and 32nd respectively on the list.
A more important figure for the upcoming Cup might be Andrew Oldcorn, who shot a 3-under 69 on Friday to end in joint ninth with six others.
At No. 15 on the list, the veteran from Scotland is trying desperately to win enough money to get into the top-10 by the BMW International Open in four weeks.
So too is another Scottish player, Andrew Coltart.
However, at 13th on the list, the younger Scot went in the opposite direction of his hopes Friday with a 4-over-par 76, which included four bogeys and a double-bogey.
Click here for full-field scores from the Celtic Manor Resort Wales Open