Eleven of the top-15 players on the money list will be on hand including Tripp Isenhour, who has gone over the $200,000 mark in just nine events. Isenhour, will be looking for a third win of the season which would earn him an automatic PGA TOUR promotion.
Standing in his way are both the defending champion in this event, Eric Axley, and the winner from two weeks ago Matt Kuchar.
Axley, in a tour rarity, will return to try and make history on the links in North Carolina. No one in the tour's 16 year history has ever successfully defended their title.
Kuchar, whose career has had its ups and downs following a stellar two-time first-team All-America career at Georgia Tech, will be hoping to build on his win at the Henrico County Open. The victory vaulted Kuchar all the way up to eighth on the Nationwide Tour money list. The top 20 at season's end receives membership onto the PGA TOUR.
Two years ago the Rex Hospital Open saw one of the longest playoffs in tour history as Chris Anderson made a par on the eighth playoff hole to defeat Brendan Jones, Paul Gow and Jason Buha.
The field will face a tough challenge in the Hale Irwin-designed 7,257-yard, par-71 TPC at Wakefield Plantation, making it one of the longest courses on the Nationwide Tour. It is one of two TPC courses to play host to a Nationwide event - the other is the TPC of Virginia Beach.
The purse this week is $450,000 with a first-place check of $94,500.
There will be no televised coverage of the event this week.