Toms ended the event at 15-under-par 269, one stroke better than Kirk Triplett (66) and four better than Charles Howell III (67) and Esteban Toledo (70).
With victory, the 35-year-old has now won three times on the PGA Tour in 2001.
He took the Compaq Classic of New Orleans in May and followed it up with the Wanamaker Trophy at this years PGA Championship.
His triumph Sunday gives him seven for his career, and since 1999, only Tiger Woods has taken more trophies. Toms is now tied with Phil Mickelson and David Duval on that mark of seven.
Equally impressive, he has now won five times on seven occasions in which he has taken a lead into the final round.
As demonstrated at the Atlanta Athletic Club, site of this years PGA, there seems to be no better closer than Toms.
He appears to be the Real Deal.
Starting the day with a two-stroke lead, Toms immediately put space between he and the rest of the field with a birdie right off the bat at the par-4 1st, and added three more over his next six holes.
One more birdie at No. 14 gave Toms some breathing room, which he would need, as he bogied the 17th.
'I got over to 17 and put a bad swing on it and obviously I made it pretty interesting here on the last hole,' said Toms.
In the meantime, Triplett was showing moments of brilliance on Sunday, rattling in three birdies on the front nine and three more over the back.
Had it not been for a lone bogey at the par-4 11th, the floppy-hat-wearing winner of the 00 Nissan Open might have had a chance in the end.
Likewise, young Howell made a good run as well, with three birdies over his last five holes, but he was just too far back thanks to a third-round 71.
In the end, it was just Toms, as he placed a 5-iron pin-high on the closing par-4 18th, and successfully two-putted for 68 and the one-shot win.
'I played some good golf this weekend,' said Toms. 'It was just solid golf tee to green.'
For the performance, Toms takes home a check worth $630,000. He moves from fifth to third on the official money list with $3.3 million.
For the year, only Woods and Mickelson stand in front of him in that race.
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