Toms, the events defending champion, carded 67 on a cold, wet Day 3 to move to 12-under-par through 54 holes.
He leads by two strokes entering the final round over Mexican native Esteban Toledo (68), and by three over four others including Kirk Triplett (69) and WORLDCOM Classic champion Jose Coceres (67).
Meanwhile, Robert Allenby - winner of the Pennsylvania Classic two weeks ago ' sits in joint seventh with two other players following a 67 of his own.
The week so far has belonged to Toms, however.
The Louisiana native and reigning PGA Champion made his intentions clear early this week with an opening round 64, but faded a bit on the second day with a 70.
He quickly rebounded on Saturday, however, as he birdied his first hole of the day and went on to record five more of the red numbers to offset just two bogies.
Toms round was climaxed at the closing par-4 18th, as he poured in a final and dramatic 40-foot birdie for a two-shot lead entering the weekend.
'I hit the ball well and kept it in the fairway and hit some good iron shots,' he said following his round.
Closest to Toms is Toledo, who, in his fifth full year on the PGA Tour, is still searching for his first win.
Like Toms, Toledos round was lessened by two bogies, but he is in prime position to top his best career finish on the PGA Tour, which came as a second at last years B.C. Open.
For young Charles Howell III, however, the prospects of an inaugural victory this week were dashed a bit on Saturday, as the former NCAA champion could do no better than 71 to end five shots back at 7-under.
The 22-year-old had it to 10-under and was leading early in the round, but three bogies over his final nine holes of the day saw him fade back.
Another who dropped off on Saturday was Bryce Molder, the recently-turned professional from Georgia Tech.
Starting the day just four off the pace, Molder struggled to a 76 and sits at even-par entering Sunday.
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