Furyk followed up his opening 63 with 4-under 66 on Friday. His 11-under-par total was good enough for a two-shot lead over Rafael Cabrera-Bello.
A pair of major championship playoff losers are in third and fourth place. Masters runner-up Louis Oosthuizen is alone in third at 8 under par. Jason Dufner, runner-up at last year's PGA Championship, is 7 under.