At 15-under-par, Fulke leads fellow Swede Henrik Nystrom. Scot Alastair Forsyth is five back at 10-under, with first-round leader Raphael Jacquelin in fourth place at 8-under.
Fulke is trying to make a complete comeback from a wrist injury, which kept him out the game for seven months. Ironically, the setback occurred shortly after he claimed his maiden victory at the Trophee Lancome.
'To win would be evidence that I am back to where I raised myself after Lancome,' said Fulke. 'It would mean a great deal. I have worked a little bit on my swing. It would show that is paying off as well.'
Following a heavy early morning shower, Fulke reeled off five birdies to just one bogey for a near flawless round of 68.
Nystrom also only dropped one shot on the day. He matched Fulke's 68 to stay within reach of his countryman. On the other hand, Forsyth fell from two down to five back of the lead with a third-round 71. Still, the 24-year-old medallist of last year's European Tour Qualifying Tournament is in contention to collect his first Tour victory.
'I'm in a bit of a chasing position, but am not going to do anything daft,' said the rookie. 'There is a chance Pierre could come back. It is a tough course. He shot great numbers so far, so maybe he has a bad day up his sleeve.'