In a day filled with fireworks, Romero holed a pitching wedge at the second, then, added another eagle at the par-5 9th. In between, 'El Gato' - the cat - carded a pair of birdies to post a front-nine score of 6-under-par 30. Romero, whose last triumph came at this event in 1994, collected three more birdies on the inward half to move to 19-under for the tournament.
Clarke tried to hang with Romero on Saturday - eagling the par-5 1st - but the Ulsterman was unable to gain any ground. In fact, despite shooting a 4-under 67, Clarke saw his overnight three-stroke deficit increase to eight.
In 1992, Jamie Spence came from 10 shots back on Sunday to win the European Masters. When reminded of Spence's closing 60 to win, Clarke replied: 'It won't be me if I keep putting the way I am.
'I played fine but missed everything - again. It's the same thing as I've been saying all week.'
Putting was a problem for Clarke's stablemate as well. Lee Westwood started the day just three shots back of Romero, but now enters the final round 15 off the lead.
While Romero went out in 30 on Saturday, Westwood did so in 40. The Englishman added 34 more shots over the back nine for a round of 3-over 74. After finishing the day at 4-under-par, Westwood was in no mood to chat with the media.
On the other hand, Romero was more than happy to discuss his record-tying round at Crans-sur-Sierre. In his broken English, Romero said: 'I played fantastic. I was a different person. I didn't see anybody - I just focus ball and flag.'
If he wins on Sunday, Romero will become the oldest champion on the European Tour since his compatriot Vicente Fernandez, also 46 at the time, holed an 87-foot putt to capture the 1992 English Open.