Brier had five birdies and one bogey on the 7,073-yard course at Shanghai Silport Golf Club to finish at 10-under 274.
Graeme McDowell of Northern Ireland (69), Andrew McLardy of South Africa (70), and Scott Hend of Australia (71) tied for second at 279.
South Africa's Richard Sterne chipped in for an eagle on No. 18 for a 70, finishing a stroke back at 280.
Brier earned $333,390 out of a purse of $2 million at the tournament co-sanctioned by the European and Asian tours.