In the eight third-round matches, Retief Goosen, the No. 1 seed in the Sam Snead bracket, was the only higher-ranked player to advance to Saturday's quarterfinal.
Phil Mickelson, the second seed in the Ben Hogan bracket could not get anything going on Friday and fell 3 and 1 to No. 3 David Howell. That sets Howell up for a quarterfinal match with Geoff Ogilvy, the 13th seed. Ogilvy won the last four holes against ninth-ranked Mike Weir, then eagled the third extra hole for the 1-up win.
Vijay Singh, tops in the Gary Player bracket, hit two terrible 3-woods late in his match against No. 5 Padraig Harrington and fell 1-down in 20 holes. Harrington meets former runner-up, Davis Love III. Love, sixth in the bracket, toppled last year's runner-up, Chris DiMarco, 3 and 2.
Goosen bested No. 4 Luke Donald, 1-up. The two-time U.S. Open champion will meet No. 15 Zach Johnson on Saturday. Johnson moved on with a 4 and 3 thrashing of No. 11 Shingo Katayama.
Campbell won the fourth hole with a birdie, then eventually built a 3-up lead through 10 holes when he rolled in a long birdie putt at 10. Woods chipped in for eagle to win the par-5 11th and captured 12 to cut the deficit to 1-down.
Campbell converted an 8-footer for birdie to take 13 and go 2-up. Unfortunately, the 19th-ranked player in the world made a mess of 14 and lost the hole. The pair halved the next three holes with pars before heading to La Costa's par-5 closing hole.
Woods drove well right of the fairway at 18 while Campbell came to rest in the left fairway bunker. Campbell laid up down the fairway, while Woods went after the green with his second, but missed right. Campbell's third spun back to 25 feet and Woods pitched to 12 feet.
Campbell lagged his par putt close enough for Woods to concede par. Woods, who holed a similar putt to win on 18 on Thursday against Robert Allenby, never flirted with the hole and was eliminated.
'He played really well,' acknowledged Woods, a two-time winner of this championship. 'I thought I did pretty good today. I didn't make a bogey and lost the match. It's frustrating.'
Weir, the 2003 Masters champion, was 4-up with four to play, then dropped the next four in a row, some with bogeys and some because of Ogilvy's outstanding play.
Neither did anything spectacular on the first two extra holes, but Ogilvy hit the best shot of the day on Friday at the par-5 third. He knocked a 3-iron from 240 yards inside 4 feet. Weir made a slightly longer putt for birdie, but Ogilvy converted the eagle putt to move on to the quarterfinals.
The Singh/Harrington match came to the 18th with the players even. Singh hit a terrible 3-wood well left of the green with his second, while Harrington laid up from the right rough. Singh got a free drop, then pitched 30 feet short of the flag while the Irishman hit his third 11 feet left of the hole.
Singh's birdie putt missed left, opening the door for Harrington. After studying the putt from every direction, Harrington's putt looked on its way to falling underground. Harrington pumped his fist, but the ball lipped out of the hole.
On the first extra hole, Singh hit another poor 3-wood that cost him any chance. Harrington two-putted from 15 feet to move on to his quarterfinal date with Love.
'Eventually he didn't finish off the match, really, and then I got a couple of breaks,' said Harrington. 'It was more or less up to Vijay. I just hold on in there and really I really struggled with my shots today, worse than yesterday. I don't know what it's going to be like tomorrow.'
Donald made a valiant effort against Goosen and holed a 20-foot birdie putt from the fringe on the last. With the added pressure, Goosen, a semifinalist last year, drained a 4-footer to win the match.
On Saturday, there will be four quarterfinal matches in the morning, then the two semifinal matches in the afternoon. Sunday's action will feature the 36-hole championship and a consolation match for third place.