Bradley Hughes, Jeff Freeman, Barry Cheesman, Tag Ridings, Kevin Durkin, Jeff Klauk and Eduardo Herrera share fifth place at 5-under-par 66.
After opening with two birdies and a bogey over his first four holes, Brisky's tee shot found the bottom of the cup for an ace at the par-3 fifth on the North Course at Crestview Country Club.
Brisky followed that up with a birdie at the par-4 seventh and the 38-year-old continued his fine play on the back nine.
He tallied a birdie at the par-3 12th and added a birdie at the par-5 14th to move to minus-6. Brisky then birdied the par-5 last to secure sole possession of the lead after the opening round.
Jason Bohn and Andre Stolz, both winners on the Nationwide Tour in 2003, finished in a group at 4-under-par 67.
They were joined by Joe Ogilvie, who tops the money list, and Ted Purdy among others in a tie for 12th.
Tyler Williamson, who could still become the first player to ever successfully defend his title on the Nationwide Tour, played the back nine first and had a solid start with two birdies and a bogey.
The 31-year-old moved to 2 under on his round with a birdie at the par-4 fourth but found trouble with a triple bogey at the par-3 eighth. Williamson recovered what he could with a birdie at the ninth to finish with a round of even-par 71.