Doug Garwood finished alone in second at 10-under-par 203 while Roger Tambellini was one shot further back at 9-under-par 204.
Daley, originally from Chestnut Hill, Penn., earned his first win on tour at the 1997 Louisiana Open. This year he is still looking for his first top-10 finish as he has missed the cut in four of eight starts.
A total of 74 returned to the course Saturday morning to complete the second round which had been suspended due to thunderstorms. Daley had finished before the rains hit Friday and after all was said and done he held a three-shot lead at the start of the third round.
Daley struggled out of the gates with two bogeys over the first four holes to fall to 10-under as swirling winds continued to plague Glenmaura National Golf Club. His competitors could fair no better and Daley's three-shot lead remained intact.
The 41-year-old recovered from the bad start with a birdie at the sixth and added another at the 10th to climb to minus 12.
Garwood moved within one of the lead after he reached 11-under with back-to-back birdies from the 10th. However, he ran into trouble with a bogey at No. 12 and dropped another shot with a bogey at the 15th.
Daley also bogeyed the 12th but responded with a birdie at the 14th to return to 12-under and a new three-shot lead.
'It was tough getting it close today because of the swirling winds,' said Daley. 'But I realized everybody was having to deal with the tough conditions at what it a very demanding golf course.'
Garwood closed the gap with a birdie at the last and will have to overcome a two-shot deficit on Sunday if he wants to earn his maiden title on the Buy.Com Tour.
'I felt comfortable out there today even though it was my first time in the final group,' said Garwood. 'I like being the hunter because it takes a little of the pressure off not having to protect the lead.'
Full-field scores from the NE Pennsylvania Classic